ATP2A3

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Full Name

ATPase, Ca++ transporting, ubiquitous

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ARUK-UCL
Calcium ion transmembrane transport Source: ARUK-UCL
Calcium ion transport Source: UniProtKB
Calcium ion transport from cytosol to endoplasmic reticulum Source: ARUK-UCL
Cellular calcium ion homeostasis Source: ARUK-UCL
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: ARUK-UCL
Ion transmembrane transport Source: Reactome
Negative regulation of receptor binding Source: ARUK-UCL
Regulation of cardiac conduction Source: Reactome
Transport across blood-brain barrier Source: ARUK-UCL

Cellular Location

Endoplasmic reticulum membrane; Nucleus membrane; Sarcoplasmic reticulum membrane

Topology

Cytoplasmic: 1-48 aa
Helical: 49-69 aa
Lumenal: 70-89 aa
Helical: 90-110 aa
Cytoplasmic: 111-253 aa
Helical: 254-273 aa
Lumenal: 274-295 aa
Helical: 296-313 aa
Cytoplasmic: 314-757 aa
Helical: 758-777 aa
Lumenal: 778-787 aa
Helical: 788-808 aa
Cytoplasmic: 809-828 aa
Helical: 829-851 aa
Lumenal: 852-897 aa
Helical: 898-917 aa
Cytoplasmic: 918-930 aa
Helical: 931-949 aa
Lumenal: 950-964 aa
Helical: 965-985 aa
Cytoplasmic: 986-999 aa