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Mouse Anti-ATP2A3 Recombinant Antibody (CBWJC-4433) (CBMAB-C5821WJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJC-4433
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-300 mapping at the N-terminus of SERCA1 of human origin.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase, Ca++ transporting, ubiquitous
Introduction
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human489
Rabbit100354976
Rat25391
Chicken395707
UniProt ID
HumanQ93084
RabbitG1T853
RatP18596
ChickenQ9YGL9
Alternative Names
ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 3; Calcium Pump 3; Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 3; ATPase, Ca++ Transporting, Ubiquitous; SR Ca(2+)-ATPase 3; EC 3.6.3.8;6 SERCA3;
Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ARUK-UCL
Calcium ion transmembrane transport Source: ARUK-UCL
Calcium ion transport Source: UniProtKB
Calcium ion transport from cytosol to endoplasmic reticulum Source: ARUK-UCL
Cellular calcium ion homeostasis Source: ARUK-UCL
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: ARUK-UCL
Ion transmembrane transport Source: Reactome
Negative regulation of receptor binding Source: ARUK-UCL
Regulation of cardiac conduction Source: Reactome
Transport across blood-brain barrier Source: ARUK-UCL
Cellular Location
Endoplasmic reticulum membrane; Nucleus membrane; Sarcoplasmic reticulum membrane
Topology
Cytoplasmic: 1-48 aa
Helical: 49-69 aa
Lumenal: 70-89 aa
Helical: 90-110 aa
Cytoplasmic: 111-253 aa
Helical: 254-273 aa
Lumenal: 274-295 aa
Helical: 296-313 aa
Cytoplasmic: 314-757 aa
Helical: 758-777 aa
Lumenal: 778-787 aa
Helical: 788-808 aa
Cytoplasmic: 809-828 aa
Helical: 829-851 aa
Lumenal: 852-897 aa
Helical: 898-917 aa
Cytoplasmic: 918-930 aa
Helical: 931-949 aa
Lumenal: 950-964 aa
Helical: 965-985 aa
Cytoplasmic: 986-999 aa
More Infomation
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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