AGR2

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]

Anterior Gradient 2, Protein Disulphide Isomerase Family Member

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.

Digestive tract morphogenesis
Mucus secretion
Negative regulation of cell death
Positive regulation of cell-substrate adhesion
Positive regulation of developmental growth
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of gene expression
Positive regulation of IRE1-mediated unfolded protein response
Positive regulation of PERK-mediated unfolded protein response
Positive regulation of protein localization to plasma membrane

Secreted; Endoplasmic reticulum