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Mouse Anti-AGR2 Recombinant Antibody (V2-611035) (CBMAB-A0188-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611035
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
AGR2 (AAH15503.1, 61 a.a. ~ 160 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Anterior Gradient 2, Protein Disulphide Isomerase Family Member
Entrez Gene ID
10551
UniProt ID
O95994
Alternative Names
AG2; GOB-4; HAG-2; XAG-2
Function
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
Biological Process
Digestive tract morphogenesis
Mucus secretion
Negative regulation of cell death
Positive regulation of cell-substrate adhesion
Positive regulation of developmental growth
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of gene expression
Positive regulation of IRE1-mediated unfolded protein response
Positive regulation of PERK-mediated unfolded protein response
Positive regulation of protein localization to plasma membrane
Cellular Location
Secreted; Endoplasmic reticulum
More Infomation

Wang, Y., Jia, M., Liang, C., Sheng, N., Wang, X., Wang, F., ... & Yuan, H. (2021). Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation. International journal of biological sciences, 17(3), 834.

Delom, F., Mohtar, M. A., Hupp, T., & Fessart, D. (2020). The anterior gradient-2 interactome. American Journal of Physiology-Cell Physiology, 318(1), C40-C47.

Moidu, N. A., Rahman, N. S. A., Syafruddin, S. E., Low, T. Y., & Mohtar, M. A. (2020). Secretion of pro-oncogenic AGR2 protein in cancer. Heliyon, 6(9), e05000.

Wang, D., Xu, Q., Yuan, Q., Jia, M., Niu, H., Liu, X., ... & Yuan, H. (2019). Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab. Oncogene, 38(18), 3458-3474.

Maurel, M., Obacz, J., Avril, T., Ding, Y. P., Papadodima, O., Treton, X., ... & Ogier‐Denis, E. (2019). Control of anterior GR adient 2 (AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation. EMBO molecular medicine, 11(6), e10120.

Tiemann, K., Garri, C., Lee, S. B., Malihi, P. D., Park, M., Alvarez, R. M., ... & Kani, K. (2019). Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Oncogene, 38(16), 3003-3018.

Zhang, Y., Xia, F., Zhang, F., Cui, Y., Wang, Q., Liu, H., & Wu, Y. (2019). miR-135b-5p enhances doxorubicin-sensitivity of breast cancer cells through targeting anterior gradient 2. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Li, J., Hu, J., Luo, Z., Zhou, C., Huang, L., Zhang, H., ... & Wang, Z. (2019). AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer. Experimental cell research, 385(1), 111644.

Delom, F., Nazaraliyev, A., & Fessart, D. (2018). The role of protein disulphide isomerase AGR2 in the tumour niche. Biology of the Cell, 110(12), 271-282.

Zhu, Q., Mangukiya, H. B., Mashausi, D. S., Guo, H., Negi, H., Merugu, S. B., ... & Li, D. (2017). Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain. The FEBS journal, 284(17), 2856-2869.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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