ADGRE2
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Full Name
Adhesion G Protein-Coupled Receptor E2
Function
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell migration
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Granulocyte chemotaxis
Inflammatory response
Regulation of mast cell degranulation
Cellular Location
Cell membrane; Ruffle membrane. Localized at the leading edge of migrating cells.
Involvement in disease
Vibratory urticaria (VBU): An autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum.
Topology
Extracellular: 24-540 aa
Helical: 541-561 aa
Cytoplasmic: 562-569 aa
Helical: 570-590 aa
Extracellular: 591-605 aa
Helical: 606-626 aa
Cytoplasmic: 627-644 aa
Helical: 645-665 aa
Extracellular: 666-683 aa
Helical: 684-704 aa
Cytoplasmic: 705-735 aa
Helical: 736-756 aa
Extracellular: 757-760 aa
Helical: 761-781 aa
Cytoplasmic: 782-823 aa
PTM
Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
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Datasheet