ADGRE1

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Adhesion G Protein-Coupled Receptor E1

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Adaptive immune response
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway

Cell membrane

Extracellular: 21-599 aa
Helical: 600-627 aa
Cytoplasmic: 628-634 aa
Helical: 635-656 aa
Extracellular: 657-666 aa
Helical: 667-690 aa
Cytoplasmic: 691-709 aa
Helical: 710-731 aa
Extracellular: 732-747 aa
Helical: 748-776 aa
Cytoplasmic: 777-794 aa
Helical: 795-814 aa
Extracellular: 815-829 aa
Helical: 830-852 aa
Cytoplasmic: 853-886 aa