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Rat Anti-ADGRE1 Recombinant Antibody (V2-43340) (CBMAB-E0265-FY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
V2-43340
Antibody Isotype
IgG2a, κ
Application
IHC-F, IHC

Basic Information

Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.2
Preservative
< 0.09% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adhesion G Protein-Coupled Receptor E1
Introduction
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
13733
UniProt ID
Q61549
Alternative Names
Emr1; Ly71; F4/80; Gpf480; TM7LN3; DD7A5-7; EGF-TM7
Function
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Biological Process
Adaptive immune response
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Cellular Location
Cell membrane
Topology
Extracellular: 21-599 aa
Helical: 600-627 aa
Cytoplasmic: 628-634 aa
Helical: 635-656 aa
Extracellular: 657-666 aa
Helical: 667-690 aa
Cytoplasmic: 691-709 aa
Helical: 710-731 aa
Extracellular: 732-747 aa
Helical: 748-776 aa
Cytoplasmic: 777-794 aa
Helical: 795-814 aa
Extracellular: 815-829 aa
Helical: 830-852 aa
Cytoplasmic: 853-886 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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