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PBK Matched Antibody Pair (845) (APMAB-845LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-PBK polyclonal antibody, 100 ug
Detection Antibody
Anti-PBK Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Alternative Names
PDZ Binding Kinase; T-LAK Cell-Originated Protein Kinase; Cancer/Testis Antigen 84; Spermatogenesis-Related Protein Kinase; MAPKK-Like Protein Kinase; Nori-3; CT84; TOPK;
Entrez Gene ID
55872
UniProt ID
Q96KB5
More Infomation

Wu, H., Qian, J., Zhou, L., Hu, T., Zhang, Y., Wang, C., ... & Gu, C. (2024). FHND004 inhibits malignant proliferation of multiple myeloma by targeting PDZ-binding kinase in MAPK pathway. Aging (Albany NY), 16(5), 4811.

Mu, W., Xie, Y., Li, J., Yan, R., Zhang, J., Liu, Y. E., & Fan, Y. (2022). High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma. World Journal of Surgical Oncology, 20(1), 22.

Miki, Y., Devi, L., Imai, Y., Minami, N., Koide, T., & Goel, S. (2020). Deletion of the PDZ-binding kinase (Pbk) gene does not affect male fertility in mice. Reproduction, Fertility and Development, 32(10), 893-902.

Mao, P., Bao, G., Wang, Y. C., Du, C. W., Yu, X., Guo, X. Y., ... & Wang, M. D. (2020). PDZ-binding kinase-dependent transcriptional regulation of CCNB2 promotes tumorigenesis and radio-resistance in glioblastoma. Translational oncology, 13(2), 287-294.

Chen, D., Cox, J., Annam, J., Weingart, M., Essien, G., Rathi, K. S., ... & Schnepp, R. W. (2020). LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase. Neoplasia, 22(6), 231-241.

Kar, A., Zhang, Y., Yacob, B. W., Saeed, J., Tompkins, K. D., Bagby, S. M., ... & Kiseljak-Vassiliades, K. (2019). Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACC. Endocrine-related cancer, 26(10), 765-778.

Warren, A. Y., Massie, C. E., Watt, K., Luko, K., Orafidiya, F., Selth, L. A., ... & Asim, M. (2019). A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer. Oncogene, 38(7), 1136-1150.

Zhang, Y., Yang, X., Wang, R., & Zhang, X. (2019). Prognostic value of PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) in patients with cancer. Journal of Cancer, 10(1), 131.

Diao, X., Yang, D., Chen, Y., & Liu, W. (2019). Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase. Bioscience Reports, 39(4), BSR20181692.

Kruthika, B. S., Jain, R., Arivazhagan, A., Bharath, R. D., Yasha, T. C., Kondaiah, P., & Santosh, V. (2019). Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma. Journal of neuro-oncology, 141, 315-325.

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For research use only. Not intended for any clinical use.

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