NTRK2 Matched Antibody Pair (823) (APMAB-823LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-NTRK2 monoclonal antibody, 100 ug

Detection Antibody

Anti-NTRK2 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Alternative Names

Neurotrophic Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase Receptor Type 2; Tropomyosin-Related Kinase B; EC 2.7.10.1; GP145-TrkB; Trk-B; TRKB; Neurotrophic Tyrosine Kinase, Receptor, Type 2;

Entrez Gene ID

4915

UniProt ID

Q16620

More Infomation

References

Goto, K., Pissaloux, D., Tirode, F., & de la Fouchardière, A. (2021). Spitz nevus with a novel TFG‐NTRK2 fusion: The first case report of NTRK2‐rearranged Spitz/Reed nevus. Journal of Cutaneous Pathology, 48(9), 1193-1196.

Pattwell, S. S., Arora, S., Cimino, P. J., Ozawa, T., Szulzewsky, F., Hoellerbauer, P., ... & Holland, E. C. (2020). A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. Nature communications, 11(1), 2977.

Pattwell, S. S., Konnick, E. Q., Liu, Y. J., Yoda, R. A., Sekhar, L. N., & Cimino, P. J. (2020). Neurotrophic receptor tyrosine kinase 2 (NTRK2) alterations in low-grade gliomas: report of a novel gene fusion partner in a Pilocytic astrocytoma and review of the literature. Case Reports in Pathology, 2020.

Wang, X., Xu, Z., Chen, X., Ren, X., Wei, J., Zhou, S., ... & Yan, Y. (2019). A tropomyosin receptor kinase family protein, NTRK2 is a potential predictive biomarker for lung adenocarcinoma. PeerJ, 7, e7125.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

NTRK2 Matched Antibody Pair (822)

Antibody Pairs

NTRK2 Matched Antibody Pair (822)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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