Rabbit Anti-NTRK2 (phospho Y706) Recombinant Antibody (BA0184) (CBMAB-0553CQ)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

BA0184

Antibody Isotype

IgG

Application

Dot, WB

Basic Information

Immunogen

Synthetic peptide within Human TrkB aa 700-800 (phospho Y706)

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. Diseases associated with NTRK2 include Obesity, Hyperphagia, And Developmental Delay and Pilocytic Astrocytoma. Among its related pathways are p70S6K Signaling and Akt Signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is NTRK3.

Entrez Gene ID

4915

UniProt ID

Q16620

Alternative Names

TRKB; trk-B; GP145-TrkB

More Infomation

References

Goto, K., Pissaloux, D., Tirode, F., & de la Fouchardière, A. (2021). Spitz nevus with a novel TFG‐NTRK2 fusion: The first case report of NTRK2‐rearranged Spitz/Reed nevus. Journal of Cutaneous Pathology, 48(9), 1193-1196.

Pattwell, S. S., Arora, S., Cimino, P. J., Ozawa, T., Szulzewsky, F., Hoellerbauer, P., ... & Holland, E. C. (2020). A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. Nature communications, 11(1), 2977.

Pattwell, S. S., Konnick, E. Q., Liu, Y. J., Yoda, R. A., Sekhar, L. N., & Cimino, P. J. (2020). Neurotrophic receptor tyrosine kinase 2 (NTRK2) alterations in low-grade gliomas: report of a novel gene fusion partner in a Pilocytic astrocytoma and review of the literature. Case Reports in Pathology, 2020.

Wang, X., Xu, Z., Chen, X., Ren, X., Wei, J., Zhou, S., ... & Yan, Y. (2019). A tropomyosin receptor kinase family protein, NTRK2 is a potential predictive biomarker for lung adenocarcinoma. PeerJ, 7, e7125.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

NTRK2 Matched Antibody Pair (822)

NTRK2 Matched Antibody Pair (823)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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