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NQO1 Matched Antibody Pair (814) (APMAB-814LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NQO1 polyclonal antibody, 100 ug
Detection Antibody
Anti-NQO1 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Alternative Names
NAD(P)H Quinone Dehydrogenase 1; Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase); NAD(P)H Dehydrogenase, Quinone 1; NAD(P)H:Quinone Oxidoreductase 1; Phylloquinone Reductase; Menadione Reductase; Quinone Reductase 1; DT-Diaphorase; Azoreductase; EC 1.6.5.2; NMOR1; DIA4;
Entrez Gene ID
1728
UniProt ID
P15559
More Infomation

Preethi, S., Arthiga, K., Patil, A. B., Spandana, A., & Jain, V. (2022). Review on NAD (P) H dehydrogenase quinone 1 (NQO1) pathway. Molecular Biology Reports, 49(9), 8907-8924.

Tsvetkov, P., Adler, J., Strobelt, R., Adamovich, Y., Asher, G., Reuven, N., & Shaul, Y. (2021). NQO1 binds and supports SIRT1 function. Frontiers in pharmacology, 12, 671929.

Rashid, M. H., Babu, D., & Siraki, A. G. (2021). Interactions of the antioxidant enzymes NAD (P) H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants. Chemico-Biological Interactions, 345, 109574.

Lee, W. S., Ham, W., & Kim, J. (2021). Roles of NAD (P) H: quinone oxidoreductase 1 in diverse diseases. Life, 11(12), 1301.

Ross, D., & Siegel, D. (2021). The diverse functionality of NQO1 and its roles in redox control. Redox Biology, 41, 101950.

Nemeikaitė-Čėnienė, A., Šarlauskas, J., Misevičienė, L., Marozienė, A., Jonušienė, V., Lesanavičius, M., & Čėnas, N. (2020). Aerobic cytotoxicity of aromatic N-oxides: The role of NAD (P) H: quinone oxidoreductase (NQO1). International journal of molecular sciences, 21(22), 8754.

Tsao, Y. C., Chang, Y. J., Wang, C. H., & Chen, L. (2020). Discovery of isoplumbagin as a novel NQO1 substrate and anti-cancer quinone. International journal of molecular sciences, 21(12), 4378.

Glorieux, C., & Calderon, P. B. (2019). Cancer cell sensitivity to redox-cycling quinones is influenced by NAD (P) H: quinone oxidoreductase 1 polymorphism. Antioxidants, 8(9), 369.

Selvakumar, R., Krishnan, D. A., Ramakrishnan, C., Velmurugan, D., & Gunasekaran, K. (2019). Identification of novel NAD (P) H dehydrogenase [quinone] 1 antagonist using computational approaches. Journal of Biomolecular Structure and Dynamics.

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For research use only. Not intended for any clinical use.

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