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Mouse Anti-AKR1C1 Recombinant Antibody (V2-611087) (CBMAB-A0240-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611087
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
AKR1C1 (AAH20216, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Aldo-Keto Reductase Family 1 Member C1
Introduction
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]
Entrez Gene ID
1645
UniProt ID
Q04828
Alternative Names
2-ALPHA-HSD; 20-ALPHA-HSD; C9; DD1; DDH; DDH1; H-37; HAKRC; MBAB; MGC8954
Function
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699).
Biological Process
Bile acid and bile salt transport Source: UniProtKB
Bile acid metabolic process Source: UniProtKB
Cellular response to jasmonic acid stimulus Source: UniProtKB
Cholesterol homeostasis Source: UniProtKB
Daunorubicin metabolic process Source: UniProtKB
Digestion Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Intestinal cholesterol absorption Source: UniProtKB
Progesterone metabolic process Source: UniProtKB
Prostaglandin metabolic process Source: GO_Central
Response to organophosphorus Source: UniProtKB
Retinal metabolic process Source: UniProtKB
Retinoid metabolic process Source: Reactome
Steroid metabolic process Source: GO_Central
Xenobiotic metabolic process
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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