GNL3 Matched Antibody Pair (490) (APMAB-490LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-GNL3 monoclonal, IgG2a antibody, 100 ug

Detection Antibody

Anti-GNL3 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Alternative Names

G Protein Nucleolar 3; Nucleostemin; Guanine Nucleotide Binding Protein-Like 3 (Nucleolar); Nucleolar GTP-Binding Protein 3; Novel Nucleolar Protein 47; E2-Induced Gene 3 Protein; E2IG3;

Entrez Gene ID

26354

UniProt ID

Q9BVP2

More Infomation

References

Quiroga-Artigas, G., de Jong, D., & Schnitzler, C. E. (2022). GNL3 is an evolutionarily conserved stem cell gene influencing cell proliferation, animal growth and regeneration in the hydrozoan Hydractinia. Open Biology, 12(9), 220120.

Dai, R., Wu, M., Zhang, Y., Zhu, Z., & Shi, J. (2021). G protein nucleolar 3 promotes Non-Hodgkin lymphoma progression by activating the Wnt/β-catenin signaling pathway. Experimental Cell Research, 409(2), 112911.

Megiorni, F., Camero, S., Pontecorvi, P., Camicia, L., Marampon, F., Ceccarelli, S., ... & Marchese, C. (2021). OTX015 epi-drug exerts antitumor effects in ovarian cancer cells by blocking GNL3-mediated radioresistance mechanisms: Cellular, molecular and computational evidence. Cancers, 13(7), 1519.

Meng, Q., Wang, L., Dai, R., Wang, J., Ren, Z., Liu, S., ... & Chen, C. (2020). Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder. Molecular Psychiatry, 25(11), 2672-2684.

Li, T., Li, L., Wu, X., Tian, K., & Wang, Y. (2019). The oncogenic role of GNL3 in the progression and metastasis of osteosarcoma. Cancer Management and Research, 11, 2179.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Mouse Anti-GNL3 Recombinant Antibody (1A1)

Mouse Anti-GNL3 Recombinant Antibody (9D5.3)

Mouse Anti-GNL3 (AA 328-427) Recombinant Antibody (CBFYE-1454)

Mouse Anti-GNL3 Recombinant Antibody (CBLG1-1425)

Mouse Anti-GNL3 Recombinant Antibody (14i158)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Second antibody and isotype control

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