Mouse Anti-GNL3 Recombinant Antibody (1A1) (CBMAB-A3509-LY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1A1

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

GNL3 (AAH01024.1, 328 a.a. ~ 427 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G Protein Nucleolar 3

Entrez Gene ID

26354

UniProt ID

Q9BVP2

Alternative Names

C77032; E2IG3; MGC800; NS

Function

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

Biological Process

Cell population proliferation Source: Ensembl
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of protein localization to chromosome, telomeric region Source: BHF-UCL
Positive regulation of protein sumoylation Source: BHF-UCL
Positive regulation of telomere maintenance Source: BHF-UCL
Regulation of cell population proliferation Source: UniProtKB
Stem cell division Source: UniProtKB
Stem cell population maintenance Source: UniProtKB

Cellular Location

Nucleus; Nucleolus. Shuttles between the nucleus and nucleolus.

More Infomation

References

Quiroga-Artigas, G., de Jong, D., & Schnitzler, C. E. (2022). GNL3 is an evolutionarily conserved stem cell gene influencing cell proliferation, animal growth and regeneration in the hydrozoan Hydractinia. Open Biology, 12(9), 220120.

Dai, R., Wu, M., Zhang, Y., Zhu, Z., & Shi, J. (2021). G protein nucleolar 3 promotes Non-Hodgkin lymphoma progression by activating the Wnt/β-catenin signaling pathway. Experimental Cell Research, 409(2), 112911.

Megiorni, F., Camero, S., Pontecorvi, P., Camicia, L., Marampon, F., Ceccarelli, S., ... & Marchese, C. (2021). OTX015 epi-drug exerts antitumor effects in ovarian cancer cells by blocking GNL3-mediated radioresistance mechanisms: Cellular, molecular and computational evidence. Cancers, 13(7), 1519.

Meng, Q., Wang, L., Dai, R., Wang, J., Ren, Z., Liu, S., ... & Chen, C. (2020). Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder. Molecular Psychiatry, 25(11), 2672-2684.

Li, T., Li, L., Wu, X., Tian, K., & Wang, Y. (2019). The oncogenic role of GNL3 in the progression and metastasis of osteosarcoma. Cancer Management and Research, 11, 2179.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

GNL3 Matched Antibody Pair (490)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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