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Mouse Anti-GNL3 (AA 328-427) Recombinant Antibody (CBFYE-1454) (CBMAB-E2082-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1454
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
GNL3 full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: IEVVKPMEAA SAILSQADAR QVVLKYTVPG YRNSLEFFTM LAQRRGMHQK GGIPNVEGAA KLLWSEWTGA SLAYYCHPPT SWTPPPYFNE SIVVDMKSGF
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 328-427

Target

Full Name
G Protein Nucleolar 3
Introduction
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
Entrez Gene ID
26354
UniProt ID
Q9BVP2
Alternative Names
G Protein Nucleolar 3; Nucleostemin; Guanine Nucleotide Binding Protein-Like 3 (Nucleolar); Nucleolar GTP-Binding Protein 3; Novel Nucleolar Protein 47; E2-Induced Gene 3 Protein; E2IG3
Function
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Biological Process
Cell population proliferation Source: Ensembl
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of protein localization to chromosome, telomeric region Source: BHF-UCL
Positive regulation of protein sumoylation Source: BHF-UCL
Positive regulation of telomere maintenance Source: BHF-UCL
Regulation of cell population proliferation Source: UniProtKB
Stem cell division Source: UniProtKB
Stem cell population maintenance Source: UniProtKB
Cellular Location
Nucleus; Nucleolus. Shuttles between the nucleus and nucleolus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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