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E2F6 Matched Antibody Pair (357) (APMAB-357LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-E2F6 polyclonal antibody, 100 ug
Detection Antibody
Anti-E2F6 Mouse polyclonal antibody, 40 ul
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]E2F6 (E2F Transcription Factor 6) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and Mitotic G1-G1/S phases. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is E2F3.Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3. Has a preference for the 5-TTTCCCGC-3 E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Alternative Names
E2F Transcription Factor 6; E2F-6; Transcription Factor E2F6;
Entrez Gene ID
1876
UniProt ID
O75461
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For research use only. Not intended for any clinical use.

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