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Mouse Anti-E2F6 Recombinant Antibody (TFE61) (CBMAB-AP1967LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
TFE61
Antibody Isotype
IgG1
Application
IF, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
E2F Transcription Factor 6
Introduction
This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]E2F6 (E2F Transcription Factor 6) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and Mitotic G1-G1/S phases. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is E2F3.Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5-TTTC[CG]CGC-3. Has a preference for the 5-TTTCCCGC-3 E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Entrez Gene ID
1876
UniProt ID
O75461
Alternative Names
E2F Transcription Factor 6; E2F-6; Transcription Factor E2F6;
Research Area
Inhibitor of E2F-dependent transcription (PubMed:9689056, PubMed:9704927, PubMed:9501179).

Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179).

Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179).

E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9704927, PubMed:9501179).

Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9689056, PubMed:9501179).

Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity).

May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179).
Biological Process
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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