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CD177 Matched Antibody Pair (206) (APMAB-206LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-CD177 monoclonal antibody, 100 ug
Detection Antibody
Anti-CD177 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
CD177 (CD177 Molecule) is a Protein Coding gene. Diseases associated with CD177 include Polycythemia and Polycythemia Vera. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is TEX101.
Alternative Names
CD177 Molecule; CD177 Antigen; Polycythemia Rubra Vera Protein 1; Human Neutrophil Alloantigen 2a; NB1 Glycoprotein; NB1 GP; HNA-2a;
Entrez Gene ID
57126
UniProt ID
Q8N6Q3
More Infomation

Browne, T., Wroe, E., Keen, L., & Poles, A. (2021). Human neutrophil antigen 2 sequence‐based typing: Joining the hunt for the CD177 answer. Vox Sanguinis.

Saha, R., Pradhan, S. S., Das, P., Mishra, P., Singh, R., Sivaramakrishnan, V., & Acharya, P. (2021). Inflammatory signature in acute-on-chronic liver failure includes increased expression of granulocyte genes ELANE, MPO and CD177. Scientific reports, 11(1), 1-16.

Dahlstrand Rudin, A., Amirbeagi, F., Davidsson, L., Khamzeh, A., Thorbert Mros, S., Thulin, P., ... & Bylund, J. (2021). The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis. Journal of Leukocyte Biology, 109(2), 349-362.

Lévy, Y., Wiedemann, A., Hejblum, B. P., Durand, M., Lefebvre, C., Surénaud, M., ... & French COVID cohort study group. (2021). CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death. Iscience, 24(7), 102711.

Kim, M. C., Borcherding, N., Ahmed, K. K., Voigt, A. P., Vishwakarma, A., Kolb, R., ... & Zhang, W. (2021). CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Nature communications, 12(1), 1-13.

Huang, Y. (2019). 4311 Decreased CD177 expression and its association with intravenous immunoglobulin resistance in Kawasaki disease. European Heart Journal, 40(Supplement_1), ehz745-0156.

Deng, H., Hu, N., Wang, C., Chen, M., & Zhao, M. H. (2018). Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA. Arthritis research & therapy, 20(1), 1-10.

Bai, M., Grieshaber-Bouyer, R., Wang, J., Schmider, A. B., Wilson, Z. S., Zeng, L., ... & Nigrovic, P. A. (2017). CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood, The Journal of the American Society of Hematology, 130(19), 2092-2100.

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For research use only. Not intended for any clinical use.

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