Fig.1 Nucleoli fibrillar center1.
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The giant fibrillar center (GFC) appeared as a round nucleolar domain (1–2 μm in diameter) partially surrounded by the dense fibrillar component and accompanied by numerous small fibrillar centers. By immunocytochemistry, the GFC concentrated the upstream binding factor, which may serve as a marker of this structure, and also contain RNA polymerase I, DNA topoisomerase I, SUMO-1 and Ubc9.
Reference
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