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CAST Matched Antibody Pair (185) (APMAB-185LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CAST polyclonal antibody, 100 ug
Detection Antibody
Anti-CAST Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Alternative Names
Calpastatin; Sperm BS-17 Component; Calpain Inhibitor; BS-17; PLACK;
Entrez Gene ID
831
UniProt ID
P20810
More Infomation

Flores-Toro, J., Chun, S. K., Shin, J. K., Campbell, J., Lichtenberger, M., Chapman, W., ... & Kim, J. S. (2021). Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers. Cells, 10(8), 1863.

Hu, D., Sun, X., Magpusao, A., Fedorov, Y., Thompson, M., Wang, B., ... & Qi, X. (2021). Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease. Nature communications, 12(1), 1-19.

Motter, M. M., Corva, P. M., & Soria, L. A. (2021). Expression of calpastatin isoforms in three skeletal muscles of Angus steers and their association with fiber type composition and proteolytic potential. Meat Science, 171, 108267.

Bozhilova-Sakova, M., Dimitrova, I., Tzonev, T. I., & Petrov, N. (2020). Genotype frequencies in calpastatin (CAST) and callipyge (CLPG) genes in Northeast Bulgarian Merino sheep breed using PCR-RFLP method. Bulgarian Journal of Agricultural Science, 26(2), 475-479.

Burchett, R., Brun, M., Monckton, E. A., Poon, H. Y., & Godbout, R. (2019). Effects of nuclear factor I phosphorylation on calpastatin (CAST) gene variant expression and subcellular distribution in malignant glioma cells. Journal of Biological Chemistry, 294(4), 1173-1188.

Wang, S., Huang, Y., Yan, Y., Zhou, H., Wang, M., Liao, L., ... & Xiong, K. (2019). Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons. Annals of Anatomy-Anatomischer Anzeiger, 221, 57-67.

Jawasreh, K. I., & Ismail, Z. B. (2019). Effects of calpastatin gene polymorphism on hematology and selected serum biochemical parameters in Awassi lambs. Journal of advanced veterinary and animal research, 6(2), 193.

Zhang, J., Wu, D., Li, Y., Fan, Y., Chen, H., & Xu, J. (2018). Evaluating the association between calpastatin (CAST) gene and keratoconus in the Han Chinese population. Gene, 653, 10-13.

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For research use only. Not intended for any clinical use.

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