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Mouse Anti-VPS72 Recombinant Antibody (CBLY2-121) (CBMAB-Y0074-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLY2-121
Antibody Isotype
IgG2a
Application
WB, ICC/IF

Basic Information

Immunogen
Human VPS72
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
vacuolar protein sorting 72 homolog (S. cerevisiae)
Introduction
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Entrez Gene ID
6944
UniProt ID
Q15906
Alternative Names
YL1; CFL1; Swc2; YL-1; TCFL1
Function
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Biological Process
Biological Process histone acetylation Source:ComplexPortal1 Publication
Biological Process histone H2A acetylation Source:ComplexPortal1 Publication
Biological Process histone H4 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ProtInc1 Publication
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of double-strand break repair via homologous recombination Source:ComplexPortal1 Publication
Biological Process regulation of apoptotic process Source:ComplexPortal1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of double-strand break repair Source:ComplexPortal1 Publication
Biological Process somatic stem cell population maintenance Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Nucleus
PTM
Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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