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Mouse Anti-VPS72 Recombinant Antibody (2G6) (CBMAB-V0054-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2G6
Antibody Isotype
IgG2a, к
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
vacuolar protein sorting 72 homolog (S. cerevisiae)
Introduction
VPS72 is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. VPS72 may be responsible for binding H2AFZ, which has a role in chromosome segregation. VPS72 may also have a role in regulating long-term hematopoietic stem cell activity.
Entrez Gene ID
6944
UniProt ID
Q15906
Alternative Names
Vacuolar Protein Sorting 72 Homolog; Transcription Factor-Like 1; TCFL1; YL1; Vacuolar Protein Sorting-Associated Protein 72 Homolog; Vacuolar Protein Sorting 72 Homolog (S. Cerevisiae); Vacuolar Protein Sorting 72 (Yeast)
Function
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Biological Process
Biological Process histone acetylation Source:ComplexPortal1 Publication
Biological Process histone H2A acetylation Source:ComplexPortal1 Publication
Biological Process histone H4 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ProtInc1 Publication
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of double-strand break repair via homologous recombination Source:ComplexPortal1 Publication
Biological Process regulation of apoptotic process Source:ComplexPortal1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of double-strand break repair Source:ComplexPortal1 Publication
Biological Process somatic stem cell population maintenance Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Nucleus
PTM
Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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