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Mouse Anti-USO1 Recombinant Antibody (CBXU-061) (CBMAB-U0172-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXU-061
Antibody Isotype
IgG1, к
Application
ELISA, ELISA (Cap), IF, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
USO1 homolog, vesicle docking protein (yeast)
Introduction
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Among its related pathways are Mitotic Prophase and Transport to the Golgi and subsequent modification.
Entrez Gene ID
8615
UniProt ID
O60763
Alternative Names
TAP; VDP; P115
Function
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Biological Process
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB
Biological Process Golgi vesicle docking Source:GO_Central1 Publication
Biological Process intracellular protein transport Source:GO_Central1 Publication
Biological Process membrane fusion Source:GO_Central1 Publication
Biological Process regulation of cellular response to insulin stimulus Source:Ensembl
Biological Process secretory granule localization Source:Ensembl
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process transcytosis Source:GO_Central1 Publication
Biological Process vesicle fusion with Golgi apparatus Source:InterPro
Cellular Location
Cytoplasm, cytosol
Golgi apparatus membrane
Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.
PTM
Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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