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Mouse Anti-USO1 Recombinant Antibody (15/p115) (CBMAB-P3772-YC)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
15/p115
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Rat p115, AA 843-955
Specificity
Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
USO1 homolog, vesicle docking protein (yeast)
Introduction
USO1 is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus.
Entrez Gene ID
Mouse56041
Rat56042
UniProt ID
MouseQ9Z1Z0
RatP41542
Alternative Names
TAP; Vdp
Function
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
Biological Process
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB
Biological Process Golgi vesicle docking Source:GO_Central1 Publication
Biological Process intracellular protein transport Source:GO_Central1 Publication
Biological Process membrane fusion Source:GO_Central1 Publication
Biological Process regulation of cellular response to insulin stimulus Source:Ensembl
Biological Process secretory granule localization Source:Ensembl
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process transcytosis Source:GO_Central1 Publication
Biological Process vesicle fusion with Golgi apparatus Source:InterPro
Cellular Location
Cytoplasm, cytosol
Golgi apparatus membrane
Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.
PTM
Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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