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Mouse Anti-TNFSF10 Antibody (12C8) (CBMAB-1651CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
12C8
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein (24.2 kDa protein fragment)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFSF10
Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. Diseases associated with TNFSF10 include Malignant Glioma and Ulceroglandular Tularemia. Among its related pathways are Dimerization of procaspase-8 and Akt Signaling.
Entrez Gene ID
8743
UniProt ID
P50591
Alternative Names
TNFSF10; TNF superfamily member 10; TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Biological Process
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process male gonad development Source:Ensembl
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB3 Publications
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB3 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of release of cytochrome c from mitochondria Source:UniProtKB1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process signal transduction Source:ProtInc2 Publications
Cellular Location
Cell membrane
Secreted
Exists both as membrane-bound and soluble form.
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-281
PTM
Tyrosine phosphorylated by PKDCC/VLK.
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For research use only. Not intended for any clinical use.

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