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Mouse Anti-TNFSF10 Recombinant Antibody (CBYJT-3903) (CBMAB-T3304-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYJT-3903
Antibody Isotype
IgG1
Application
WB, ELISA, Neut, Inhib

Basic Information

Immunogen
Recombinant full length protein (Human).
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFSF10
Introduction
TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TNFSF10 binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TNFSF10 to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Entrez Gene ID
Human8743
Mouse22035
UniProt ID
HumanP50591
MouseP50592
Alternative Names
TNF Superfamily Member 10; Tumor Necrosis Factor (Ligand) Superfamily, Member 10; Apo-2 Ligand; Apo-2L; APO2L; TRAIL; Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta; Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10; Tumor Necrosis Factor Ligand Superfamily Member 10; Tumor Necrosis Factor (Ligand) Family, Member 10
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Biological Process
Biological Process apoptotic process Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process male gonad development Source:Ensembl
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:UniProtKB3 Publications
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB3 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process positive regulation of release of cytochrome c from mitochondria Source:UniProtKB1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process signal transduction Source:ProtInc2 Publications
Cellular Location
Cell membrane
Secreted
Exists both as membrane-bound and soluble form.
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-281
PTM
Tyrosine phosphorylated by PKDCC/VLK.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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