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Rat Anti-TNFRSF19 Recombinant Antibody (CBYJT-3782) (CBMAB-T3166-YJ)


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Summary

Host Animal
Rat
Specificity
Human
Clone
CBYJT-3782
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Recombinant protein corresponding to aa1-168 of human TAJ fused at the cysteine-rich domain to the Fc portion of human IgG1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-168

Target

Full Name
TNFRSF19 Gene(Protein Coding) TNF Receptor Superfamily Member 19
Introduction
TNFRSF19 is a member of the TNF-receptor superfamily. It is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. It is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an necessary role in embryonic development.
Entrez Gene ID
55504
UniProt ID
Q9NS68
Alternative Names
TNF Receptor Superfamily Member 19; Toxicity And JNK Inducer; TRADE; TROY; TAJ; Tumor Necrosis Factor Receptor Superfamily, Member 19; Tumor Necrosis Factor Receptor Superfamily Member 19; TAJ-Alpha
Function
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
Biological Process
Biological Process apoptotic process Source:UniProtKB1 Publication
Biological Process hair follicle development Source:Ensembl
Biological Process JNK cascade Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process positive regulation of JNK cascade Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Extracellular: 30-170
Helical: 171-191
Cytoplasmic: 192-423
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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