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Mouse Anti-TMPO Recombinant Antibody (6E10) (CBMAB-L2679-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle
Clone
6E10
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide: GEQRKDVYVQLYLQHLTARNRP, corresponding to amino acids 29-50 of Human LAP2, common to all isoforms.
Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM PBS, pH 7.4
Preservative
15mM Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 29-50

Target

Full Name
Thymopoietin
Introduction
TMPO resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. TMPO may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Entrez Gene ID
Human7112
Mouse21917
Rat25359
Cattle510267
UniProt ID
HumanP42166
MouseQ61033
RatQ62733
CattleA5D7N8
Alternative Names
Thymopoietin; Thymopoietin-Related Peptide Isoforms Beta/Gamma; Thymopoietin-Related Peptide Isoform Alpha; LEM Domain Containing 4; TP Beta/Gamma; TP Alpha; LAP2; Thymopoietin, Isoforms Beta/Gamma; Lamina-Associated Polypeptide 2
Function
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Cellular Location
Nucleus
Chromosome
Expressed diffusely throughout the nucleus.
PTM
Phosphorylated in a mitose-specific manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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