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Rat Anti-Timd2 Recombinant Antibody (CBYJT-3147) (CBMAB-T2418-YJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-3147
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse TIM-2
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
T Cell Immunoglobulin And Mucin Domain Containing 2
Introduction
Timd2 is a probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation.
Entrez Gene ID
171284
UniProt ID
Q8R183
Alternative Names
G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662
Function
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Biological Process
Biological Process iron ion transportSource:MGI1 Publication
Biological Process phagocytosis, engulfmentSource:GO_Central1 Publication
Biological Process positive regulation of mast cell activationSource:GO_Central1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-231
Helical: 232-252
Cytoplasmic: 253-305
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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