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Mouse Anti-TCF12 Recombinant Antibody (CBYJT-2247) (CBMAB-T1356-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2247
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant fragment corresponding to Human TCF12 aa 108-520. Sequence: MGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYY SFSATSSRRRPLHDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRE SPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTST SHMSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPY VAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFP SNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRL DDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLV ASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQ SQSGTVVTTEIKT
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 108-520

Target

Full Name
TCF12 Gene(Protein Coding) Transcription Factor 12
Introduction
TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. TCF12 is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins.
Entrez Gene ID
6938
UniProt ID
Q99081
Alternative Names
Transcription Factor 12; Class B Basic Helix-Loop-Helix Protein 20; Helix-Loop-Helix Transcription Factor 4; Transcription Factor HTF-4; DNA-Binding Protein HTF4; E-Box-Binding Protein; BHLHb20
Function
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIDA:NTNU_SB1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Craniosynostosis 3 (CRS3):
A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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