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Mouse Anti-TCF12 Recombinant Antibody (2E9) (CBMAB-A8943-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TCF12 (NP_996919, 364 a.a. ~ 453 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TCF12 Gene(Protein Coding) Transcription Factor 12
Introduction
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]
Entrez Gene ID
6938
UniProt ID
Q99081
Alternative Names
HEB; HTF4; HsT17266; bHLHb20
Function
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process immune responseTAS:ProtInc1 Publication
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIDA:NTNU_SB1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Craniosynostosis 3 (CRS3):
A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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