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Rabbit Anti-TACR1 Recombinant Antibody (BA0322) (CBMAB-0860CQ)

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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0322
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Human Neurokinin 1 Receptor aa 350 to the C-terminus
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tachykinin receptor 1
Introduction
This gene belongs to a gene family of tachykinin receptors.The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.
Entrez Gene ID
Human6869
Mouse21336
Rat24807
UniProt ID
HumanP25103
MouseP30548
RatP14600
Alternative Names
SPR; NK1R; NKIR; TAC1R
Function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P> substance K> neuromedin-K.
Biological Process
Biological Process acute inflammatory responseIEA:Ensembl
Biological Process aggressive behaviorIEA:Ensembl
Biological Process angiotensin-mediated drinking behaviorIEA:Ensembl
Biological Process associative learningIEA:Ensembl
Biological Process behavioral response to painIEA:Ensembl
Biological Process detection of abiotic stimulusTAS:ProtInc1 Publication
Biological Process eating behaviorIEA:Ensembl
Biological Process inflammatory responseTAS:ProtInc1 Publication
Biological Process long-term memoryIEA:Ensembl
Biological Process operant conditioningIEA:Ensembl
Biological Process phospholipase C-activating G protein-coupled receptor signaling pathwayTAS:ProtInc1 Publication
Biological Process positive regulation of action potentialIEA:Ensembl
Biological Process positive regulation of blood pressureIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB1 Publication
Biological Process positive regulation of epithelial cell migrationIEA:Ensembl
Biological Process positive regulation of epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of flagellated sperm motilityIMP:UniProtKB1 Publication
Biological Process positive regulation of hormone secretionIEA:Ensembl
Biological Process positive regulation of leukocyte migrationIEA:Ensembl
Biological Process positive regulation of lymphocyte proliferationIEA:Ensembl
Biological Process positive regulation of ossificationIEA:Ensembl
Biological Process positive regulation of renal sodium excretionIEA:Ensembl
Biological Process positive regulation of saliva secretionIEA:Ensembl
Biological Process positive regulation of stress fiber assemblyIEA:Ensembl
Biological Process positive regulation of synaptic transmission, cholinergicIEA:Ensembl
Biological Process positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Biological Process positive regulation of uterine smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vascular permeabilityIEA:Ensembl
Biological Process positive regulation of vasoconstrictionIEA:Ensembl
Biological Process regulation of smooth muscle cell migrationIEA:Ensembl
Biological Process regulation of smooth muscle cell proliferationIEA:Ensembl
Biological Process response to auditory stimulusIEA:Ensembl
Biological Process response to electrical stimulusIEA:Ensembl
Biological Process response to estradiolIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process response to heatIEA:Ensembl
Biological Process response to morphineIEA:Ensembl
Biological Process response to nicotineIEA:Ensembl
Biological Process response to ozoneIEA:Ensembl
Biological Process response to progesteroneIEA:Ensembl
Biological Process sensory perception of painIEA:Ensembl
Biological Process smooth muscle contraction involved in micturitionIEA:Ensembl
Biological Process sperm ejaculationIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayIDA:BHF-UCL1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 1-31
Helical: 32-54
Cytoplasmic: 55-64
Helical: 65-86
Extracellular: 87-106
Helical: 107-128
Cytoplasmic: 129-148
Helical: 149-169
Extracellular: 170-194
Helical: 195-219
Cytoplasmic: 220-248
Helical: 249-270
Extracellular: 271-283
Helical: 284-308
Cytoplasmic: 309-407
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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