TACR1

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq]

tachykinin receptor 1

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P> substance K> neuromedin-K.

Biological Process acute inflammatory responseIEA:Ensembl
Biological Process aggressive behaviorIEA:Ensembl
Biological Process angiotensin-mediated drinking behaviorIEA:Ensembl
Biological Process associative learningIEA:Ensembl
Biological Process behavioral response to painIEA:Ensembl
Biological Process detection of abiotic stimulusTAS:ProtInc1 Publication
Biological Process eating behaviorIEA:Ensembl
Biological Process inflammatory responseTAS:ProtInc1 Publication
Biological Process long-term memoryIEA:Ensembl
Biological Process operant conditioningIEA:Ensembl
Biological Process phospholipase C-activating G protein-coupled receptor signaling pathwayTAS:ProtInc1 Publication
Biological Process positive regulation of action potentialIEA:Ensembl
Biological Process positive regulation of blood pressureIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB1 Publication
Biological Process positive regulation of epithelial cell migrationIEA:Ensembl
Biological Process positive regulation of epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of flagellated sperm motilityIMP:UniProtKB1 Publication
Biological Process positive regulation of hormone secretionIEA:Ensembl
Biological Process positive regulation of leukocyte migrationIEA:Ensembl
Biological Process positive regulation of lymphocyte proliferationIEA:Ensembl
Biological Process positive regulation of ossificationIEA:Ensembl
Biological Process positive regulation of renal sodium excretionIEA:Ensembl
Biological Process positive regulation of saliva secretionIEA:Ensembl
Biological Process positive regulation of stress fiber assemblyIEA:Ensembl
Biological Process positive regulation of synaptic transmission, cholinergicIEA:Ensembl
Biological Process positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Biological Process positive regulation of uterine smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vascular permeabilityIEA:Ensembl
Biological Process positive regulation of vasoconstrictionIEA:Ensembl
Biological Process regulation of smooth muscle cell migrationIEA:Ensembl
Biological Process regulation of smooth muscle cell proliferationIEA:Ensembl
Biological Process response to auditory stimulusIEA:Ensembl
Biological Process response to electrical stimulusIEA:Ensembl
Biological Process response to estradiolIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process response to heatIEA:Ensembl
Biological Process response to morphineIEA:Ensembl
Biological Process response to nicotineIEA:Ensembl
Biological Process response to ozoneIEA:Ensembl
Biological Process response to progesteroneIEA:Ensembl
Biological Process sensory perception of painIEA:Ensembl
Biological Process smooth muscle contraction involved in micturitionIEA:Ensembl
Biological Process sperm ejaculationIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayIDA:BHF-UCL1 Publication

Cell membrane

Extracellular: 1-31
Helical: 32-54
Cytoplasmic: 55-64
Helical: 65-86
Extracellular: 87-106
Helical: 107-128
Cytoplasmic: 129-148
Helical: 149-169
Extracellular: 170-194
Helical: 195-219
Cytoplasmic: 220-248
Helical: 249-270
Extracellular: 271-283
Helical: 284-308
Cytoplasmic: 309-407