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Mouse Anti-SYP Monoclonal Antibody (SY38) (CBMAB-1584-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Hamster, Cattle
Clone
SY38
Antibody Isotype
IgG1
Application
FC, ICC, IF, IHC-Fr, IHC-P, WB

Basic Information

Immunogen
Presynaptic vesicles
Specificity
Human, Mouse, Rat, Hamster, Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synaptophysin
Introduction
SYP is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.
Entrez Gene ID
Human6855
Mouse20977
Rat24804
Hamster101830475
Cattle280937
UniProt ID
HumanP08247
MouseQ62277
RatP07825
HamsterA0A1U7QSJ6
CattleP20488
Alternative Names
MRX96; MRXSYP
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Biological Process
Biological Process cellular response to organic substanceIEA:Ensembl
Biological Process endocytosisISS:UniProtKB
Biological Process regulation of long-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIBA:GO_Central1 Publication
Biological Process regulation of opioid receptor signaling pathwayISS:UniProtKB
Biological Process regulation of short-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process synaptic vesicle endocytosisIEA:Ensembl
Biological Process synaptic vesicle maturationNAS:UniProtKB1 Publication
Biological Process synaptic vesicle membrane organizationNAS:UniProtKB1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Involvement in disease
Intellectual developmental disorder, X-linked 96 (XLID96):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Topology
Cytoplasmic: 1-25
Helical: 26-49
Vesicular: 50-106
Helical: 107-130
Cytoplasmic: 131-137
Helical: 138-161
Vesicular: 162-199
Helical: 200-223
Cytoplasmic: 224-313
PTM
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.
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For research use only. Not intended for any clinical use.

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