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Mouse Anti-SYP Recombinant Antibody (CBXS-2972) (CBMAB-S5719-CQ)


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Summary

Host Animal
Mouse
Specificity
Cat, Hamster, Human, Pig, Rat
Clone
CBXS-2972
Antibody Isotype
IgM
Application
ELISA, IHC, WB

Basic Information

Immunogen
Crude human synaptic immunoprecipitate
Specificity
Cat, Hamster, Human, Pig, Rat
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synaptophysin
Introduction
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR).
Entrez Gene ID
Human6855
Cat101084343
Rat24804
Hamster101830475
Pig100512029
UniProt ID
HumanP08247
CatM3W115
RatP07825
HamsterA0A1U7QSJ6
PigF1RW46
Alternative Names
MRX96; MRXSYP
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Biological Process
Biological Process cellular response to organic substanceIEA:Ensembl
Biological Process endocytosisISS:UniProtKB
Biological Process regulation of long-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIBA:GO_Central1 Publication
Biological Process regulation of opioid receptor signaling pathwayISS:UniProtKB
Biological Process regulation of short-term neuronal synaptic plasticityISS:UniProtKB
Biological Process regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process synaptic vesicle endocytosisIEA:Ensembl
Biological Process synaptic vesicle maturationNAS:UniProtKB1 Publication
Biological Process synaptic vesicle membrane organizationNAS:UniProtKB1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Involvement in disease
Intellectual developmental disorder, X-linked 96 (XLID96):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Topology
Cytoplasmic: 1-25
Helical: 26-49
Vesicular: 50-106
Helical: 107-130
Cytoplasmic: 131-137
Helical: 138-161
Vesicular: 162-199
Helical: 200-223
Cytoplasmic: 224-313
PTM
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Phosphorylated by SRC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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