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Mouse Anti-ST13 Recombinant Antibody (CBFYH-2783) (CBMAB-H0445-FY)


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Summary

Host Animal
Mouse
Specificity
Chicken, Human, Mouse, Rabbit
Clone
CBFYH-2783
Antibody Isotype
IgG
Application
FC, ICC, IF, IP, WB

Basic Information

Immunogen
Recombinant human Hip protein
Specificity
Chicken, Human, Mouse, Rabbit
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Antiserum
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ST13, Hsp70 Interacting Protein
Introduction
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
Human6767
Mouse70356
Rabbit100354640
UniProt ID
HumanP50502
MouseQ99L47
ChickenQ5ZLF0
Alternative Names
ST13, Hsp70 Interacting Protein; Progesterone Receptor-Associated P48 Protein; Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein); Suppression Of Tumorigenicity 13 Protein; Renal Carcinoma Antigen NY-REN-33; Putative Tumor Suppressor ST13; Aging-Associated Protein 2; FAM10A1; AAG2; SNC6; HIP; Testis Secretory Sperm-Binding Protein Li 233m
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).
Biological Process
Biological Process chaperone cofactor-dependent protein refoldingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein foldingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process response to bacteriumIEA:Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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