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Mouse Anti-SORD Recombinant Antibody (1C2) (CBMAB-A8457-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1C2
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SORD (NP_003095, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sorbitol Dehydrogenase
Entrez Gene ID
Human6652
Mouse20322
Rat24788
UniProt ID
HumanQ00796
MouseQ64442
RatP27867
Alternative Names
SORD1
Function
Polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415).
Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:29966615, PubMed:25105142).
May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369).
May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP+ as the electron acceptor (PubMed:3365415).
Biological Process
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process fructose biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process glucuronate catabolic process to xylulose 5-phosphateIEA:Ensembl
Biological Process L-xylitol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-xylitol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to cadmium ionIEA:Ensembl
Biological Process response to copper ionIEA:Ensembl
Biological Process response to hormoneIEA:Ensembl
Biological Process response to nutrient levelsIEA:Ensembl
Biological Process response to osmotic stressIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sorbitol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion membrane
Cell projection, cilium, flagellum
Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
Involvement in disease
Sorbitol dehydrogenase deficiency with peripheral neuropathy (SORDD):
An autosomal recessive disorder characterized by motor axonal neuropathy, slowly progressive distal muscle weakness mainly affecting the lower limbs, difficulty walking, and increased serum sorbitol. Additional variable features are distal sensory impairment, upper limb tremor, scoliosis, and mild hearing loss.
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For research use only. Not intended for any clinical use.

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