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Mouse Anti-SMNDC1 Monoclonal Antibody (2E7) (CBMAB-0142-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E7
Antibody Isotype
IgG2b
Application
IP, ELISA, WB

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SMNDC1
Introduction
This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. Necessary for spliceosome assembly. Overexpression causes apoptosis.
Entrez Gene ID
10285
UniProt ID
O75940
Alternative Names
SMNR; SPF30; TDRD16C
Function
Involved in spliceosome assembly.
Biological Process
Biological Process apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus speckle
Nucleus, Cajal body
Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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