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Mouse Anti-SLC18A1 Recombinant Antibody (CBXS-4734) (CBMAB-S1963-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4734
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 18 (vesicular monoamine), member 1
Introduction
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).
Entrez Gene ID
6570
UniProt ID
P54219
Alternative Names
Solute Carrier Family 18 Member A1; Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 1; Solute Carrier Family 18 Member 1; Vesicular Amine Transporter 1; VMAT1; VAT1; Solute Carrier Family 18 (Vesicular Monoamine), Member 1; Chromaffin Granule Amine Transporter; CGAT;
Function
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.
Biological Process
Biological Process aminergic neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process monoamine transportManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Isoform 1
Cytoplasmic vesicle membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Annotation
Isoform 2
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-21
Helical: 22-42
Lumenal: 43-138
Helical: 139-158
Cytoplasmic: 159-167
Helical: 168-188
Lumenal: 189-197
Helical: 198-218
Cytoplasmic: 219-227
Helical: 228-250
Lumenal: 251-256
Helical: 257-279
Cytoplasmic: 280-299
Helical: 300-319
Lumenal: 320-335
Helical: 336-360
Cytoplasmic: 361-365
Helical: 366-386
Lumenal: 387-391
Helical: 392-412
Cytoplasmic: 413-422
Helical: 423-443
Lumenal: 444-448
Helical: 449-470
Cytoplasmic: 471-525
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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