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Mouse Anti-SART1 Recombinant Antibody (2A9) (CBMAB-0799CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A9
Antibody Isotype
IgG1
Application
WB, ICC

Basic Information

Immunogen
Recombinant human SART1 Asn647-Lys800
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SART1, U4/U6.U5 Tri-SnRNP-Associated Protein 1
Introduction
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
Entrez Gene ID
9092
UniProt ID
O43290
Alternative Names
Ara1; HOMS1; Snu66; SART1259; SNRNP110
Function
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
Biological Process
Biological Process maturation of 5S rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA cis splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Nucleus
Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.
PTM
Sumoylated with SUMO2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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