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Mouse Anti-SART1 Recombinant Antibody (CBXS-1958) (CBMAB-S4734-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1958
Antibody Isotype
IgG1
Application
WB, ICC

Basic Information

Immunogen
Recombinant human SART1, Asn647-Lys800, Accession # O43290
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SART1, U4/U6.U5 Tri-SnRNP-Associated Protein 1
Introduction
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
Entrez Gene ID
9092
UniProt ID
O43290
Alternative Names
SART1, U4/U6.U5 Tri-SnRNP-Associated Protein 1; Squamous Cell Carcinoma Antigen Recognized By T-Cells 1; Squamous Cell Carcinoma Antigen Recognised By T Cells; Small Nuclear Ribonucleoprotein 110kDa (U4/U6.U5); U4/U6.U5 Tri-SnRNP-Associated 110 KDa Protein; Hypoxia Associated Factor; SNU66 Homolog; HSART-1; SART-1; HSnu66; Squamous Cell Carcinoma Antigen Recognized By T Cells 1; U4/U6.U5 Tri-SnRNP-Associated Protein 1;
Function
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
Biological Process
Biological Process maturation of 5S rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA cis splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cytotoxic T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Nucleus
Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.
PTM
Sumoylated with SUMO2.
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For research use only. Not intended for any clinical use.

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