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Mouse Anti-SAG Recombinant Antibody (CBXS-0114) (CBMAB-S3109-CQ)


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Summary

Host Animal
Mouse
Specificity
Pig
Clone
CBXS-0114
Antibody Isotype
IgG1
Application
IF, IHC-Fr, WB

Basic Information

Specificity
Pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Tris-glycine, 150 mM sodium chloride, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
S-antigen visual arrestin
Introduction
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.
Entrez Gene ID
397151
UniProt ID
P79260
Alternative Names
S-Antigen Visual Arrestin; S-Antigen; Retina And Pineal Gland (Arrestin); Rod Photoreceptor Arrestin; 48 KDa Protein; Rod Arrestin; Arrestin 1;
Function
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity).
May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049).
Biological Process
Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor internalizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process rhodopsin mediated signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell projection, cilium, photoreceptor outer segment
Membrane
Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity).
Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866).
Involvement in disease
Night blindness, congenital stationary, Oguchi type 1 (CSNBO1):
A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.
Retinitis pigmentosa 47 (RP47):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

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