SAG

Full Name
SAG
Function
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity).
May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049).
Biological Process
Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor internalizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process rhodopsin mediated signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell projection, cilium, photoreceptor outer segment
Membrane
Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity).
Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866).
Involvement in disease
Night blindness, congenital stationary, Oguchi type 1 (CSNBO1):
A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.
Retinitis pigmentosa 47 (RP47):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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Anti-SAG antibodies

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Mouse Anti-SAG Recombinant Antibody (CBXS-3509) (CBMAB-S6238-CQ)

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Target: SAG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Pig
Clone: CBXS-3509
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-SAG (C-Term) Recombinant Antibody (CBXS-2483) (CBMAB-S5240-CQ)

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Target: SAG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Human, Pig, Rat
Clone: CBXS-2483
Application*: IF, WB
Datasheet SDS

Mouse Anti-SAG Recombinant Antibody (CBXS-0114) (CBMAB-S3109-CQ)

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Target: SAG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBXS-0114
Application*: IF, C, WB
Datasheet SDS

Mouse Anti-SAG Recombinant Antibody (PDS-1) (CBMAB-S0176-CQ)

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Target: SAG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Cattle
Clone: PDS-1
Application*: IF, C, WB
Datasheet SDS

Mouse Anti-SAG Recombinant Antibody (S128) (CBMAB-R4010-CN)

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Target: SAG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Human, Pig
Clone: S128
Application*: WB, C, IF
Datasheet SDS

Mouse Anti-SAG Recombinant Antibody (PDS1) (CBMAB-V0245-LY)

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Target: SAG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Human, Rat, Goat, Sheep, Cattle
Clone: PDS1
Application*: E, IH, P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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