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Mouse Anti-RFXANK Recombinant Antibody (2B6) (CBMAB-R2389-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B6
Antibody Isotype
IgG2b
Application
IF, IHC, WB

Basic Information

Immunogen
A full length human recombinant protein of human RFXANK produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5-1 mg/mL

Target

Full Name
Regulatory Factor X Associated Ankyrin Containing Protein
Introduction
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]
Entrez Gene ID
8625
UniProt ID
O14593
Alternative Names
Regulatory Factor X Associated Ankyrin Containing Protein; Regulatory Factor X Subunit B; Ankyrin Repeat-Containing Regulatory Factor X-Associated Protein; Regulatory Factor X-Associated Ankyrin-Containing Protein; Ankyrin Repeat Family A Protein 1; DNA-Binding Protein RFXANK; RFX-Bdelta4;
Function
Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724).
May also potentiate the activation of RAF1 (By similarity).
Isoform 2 is not involved in the positive regulation of MHC class II genes.
Biological Process
Biological Process positive regulation of MHC class II biosynthetic process1 PublicationIC:ComplexPortal
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Biological Process Ras protein signal transductionIEA:Ensembl
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Bare lymphocyte syndrome 2 (BLS2):
A severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
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For research use only. Not intended for any clinical use.

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