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Mouse Anti-PATZ1 Recombinant Antibody (D-5) (CBMAB-P0848-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
D-5
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
POZ (BTB) and AT hook containing zinc finger 1
Introduction
PATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
Entrez Gene ID
23598
UniProt ID
Q9HBE1
Alternative Names
POZ/BTB And AT Hook Containing Zinc Finger 1; Zinc Finger Protein 278; Protein Kinase A RI Subunit Alpha-Associated Protein; Zinc Finger And BTB Domain-Containing Protein 19; Zinc Finger Sarcoma Gene Protein; ZNF278; ZBTB19; PATZ; RIAZ; ZSG;
Function
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552).
Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280).
Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552).
(Microbial infection) Plays a positive role in viral cDNA synthesis.
Biological Process
Male gonad developmentIEA:Ensembl
Negative regulation of endothelial cell migrationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of transcription, DNA-templatedIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
SpermatogenesisIEA:Ensembl
T cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.
More Infomation

Kim, H., Lee, K., Phi, J. H., Paek, S. H., Yun, H., Choi, S. H., & Park, S. H. (2023). Neuroepithelial tumor with EWSR1:: PATZ1 fusion: A literature review. Journal of Neuropathology & Experimental Neurology, 82(11), 934-947.

Lucà, S., Franco, R., Napolitano, A., Soria, V., Ronchi, A., Zito Marino, F., ... & Fedele, M. (2023). PATZ1 in non-small cell lung cancer: a new biomarker that negatively correlates with PD-L1 expression and suppresses the malignant phenotype. Cancers, 15(7), 2190.

Mancinelli, S., Vitiello, M., Donnini, M., Mantile, F., Palma, G., Luciano, A., ... & Fedele, M. (2021). The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation. Frontiers in Cell and Developmental Biology, 9, 657149.

Alhalabi, K. T., Stichel, D., Sievers, P., Peterziel, H., Sommerkamp, A. C., Sturm, D., ... & Jones, D. T. (2021). PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta neuropathologica, 142(5), 841-857.

Al-Obaidy, K. I., Bridge, J. A., Cheng, L., Sumegi, J., Reuter, V. E., Benayed, R., ... & Grignon, D. J. (2021). EWSR1-PATZ1 fusion renal cell carcinoma: a recurrent gene fusion characterizing thyroid-like follicular renal cell carcinoma. Modern Pathology, 34(10), 1921-1934.

Park, K. W., Cai, Y., Benjamin, T., Qorbani, A., & George, J. (2020). Round cell sarcoma with EWSR1‐PATZ1 gene fusion in the neck: Case report and review of the literature. The Laryngoscope, 130(12), E833-E836.

Chougule, A., Taylor, M. S., Nardi, V., Chebib, I., Cote, G. M., Choy, E., ... & Deshpande, V. (2019). Spindle and round cell sarcoma with EWSR1-PATZ1 gene fusion: a sarcoma with polyphenotypic differentiation. The American journal of surgical pathology, 43(2), 220-228.

Siegfried, A., Rousseau, A., Maurage, C. A., Pericart, S., Nicaise, Y., Escudie, F., ... & Uro‐Coste, E. (2019). EWSR1‐PATZ1 gene fusion may define a new glioneuronal tumor entity. Brain Pathology, 29(1), 53-62.

Bridge, J. A., Sumegi, J., Druta, M., Bui, M. M., Henderson-Jackson, E., Linos, K., ... & Brohl, A. S. (2019). Clinical, pathological, and genomic features of EWSR1-PATZ1 fusion sarcoma. Modern Pathology, 32(11), 1593-1604.

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For research use only. Not intended for any clinical use.

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