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Mouse Anti-PATZ1 Recombinant Antibody (CBWJZ-186) (CBMAB-Z0467-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-186
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PATZ1 (AA260-358) partial recombinant protein with GST tag. Immunogen sequence: PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS RTRKQVACE
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
POZ (BTB) and AT hook containing zinc finger 1
Introduction
PATZ1 (POZ/BTB And AT Hook Containing Zinc Finger 1) is a Protein Coding gene. Diseases associated with PATZ1 include Sarcoma. Among its related pathways are Coregulation of Androgen receptor activity and Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is MAZ.
Entrez Gene ID
23598
UniProt ID
Q9HBE1
Alternative Names
ZSG; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; dJ400N23
Function
Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552).
Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280).
Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552).
(Microbial infection) Plays a positive role in viral cDNA synthesis.
Biological Process
Male gonad developmentIEA:Ensembl
Negative regulation of endothelial cell migrationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of transcription, DNA-templatedIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
SpermatogenesisIEA:Ensembl
T cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.
More Infomation

Kim, H., Lee, K., Phi, J. H., Paek, S. H., Yun, H., Choi, S. H., & Park, S. H. (2023). Neuroepithelial tumor with EWSR1:: PATZ1 fusion: A literature review. Journal of Neuropathology & Experimental Neurology, 82(11), 934-947.

Lucà, S., Franco, R., Napolitano, A., Soria, V., Ronchi, A., Zito Marino, F., ... & Fedele, M. (2023). PATZ1 in non-small cell lung cancer: a new biomarker that negatively correlates with PD-L1 expression and suppresses the malignant phenotype. Cancers, 15(7), 2190.

Mancinelli, S., Vitiello, M., Donnini, M., Mantile, F., Palma, G., Luciano, A., ... & Fedele, M. (2021). The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation. Frontiers in Cell and Developmental Biology, 9, 657149.

Alhalabi, K. T., Stichel, D., Sievers, P., Peterziel, H., Sommerkamp, A. C., Sturm, D., ... & Jones, D. T. (2021). PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta neuropathologica, 142(5), 841-857.

Al-Obaidy, K. I., Bridge, J. A., Cheng, L., Sumegi, J., Reuter, V. E., Benayed, R., ... & Grignon, D. J. (2021). EWSR1-PATZ1 fusion renal cell carcinoma: a recurrent gene fusion characterizing thyroid-like follicular renal cell carcinoma. Modern Pathology, 34(10), 1921-1934.

Park, K. W., Cai, Y., Benjamin, T., Qorbani, A., & George, J. (2020). Round cell sarcoma with EWSR1‐PATZ1 gene fusion in the neck: Case report and review of the literature. The Laryngoscope, 130(12), E833-E836.

Chougule, A., Taylor, M. S., Nardi, V., Chebib, I., Cote, G. M., Choy, E., ... & Deshpande, V. (2019). Spindle and round cell sarcoma with EWSR1-PATZ1 gene fusion: a sarcoma with polyphenotypic differentiation. The American journal of surgical pathology, 43(2), 220-228.

Siegfried, A., Rousseau, A., Maurage, C. A., Pericart, S., Nicaise, Y., Escudie, F., ... & Uro‐Coste, E. (2019). EWSR1‐PATZ1 gene fusion may define a new glioneuronal tumor entity. Brain Pathology, 29(1), 53-62.

Bridge, J. A., Sumegi, J., Druta, M., Bui, M. M., Henderson-Jackson, E., Linos, K., ... & Brohl, A. S. (2019). Clinical, pathological, and genomic features of EWSR1-PATZ1 fusion sarcoma. Modern Pathology, 32(11), 1593-1604.

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For research use only. Not intended for any clinical use.

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