Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-OTX2 Recombinant Antibody (14H14L5) (CBMAB-0563CQ)


See all OTX2 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human
Clone
14H14L5
Antibody Isotype
IgG
Application
FC, IF, WB

Basic Information

Immunogen
Peptides from Human OTX2 (aa 20-39, 276-289)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Orthodenticle Homeobox 2
Introduction
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5-TCTAATCCC-3.
Entrez Gene ID
5015
UniProt ID
P32243
Alternative Names
CPHD6; MCOPS5
Function
Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Biological Process
Axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Dopaminergic neuron differentiationManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Forebrain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Midbrain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of embryonic developmentISS:UniProtKB
Positive regulation of gastrulationISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Primitive streak formationISS:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of smoothened signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Microphthalmia, syndromic, 5 (MCOPS5):
Patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including pituitary dysfunction, coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
Pituitary hormone deficiency, combined, 6 (CPHD6):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD6 patients manifest neonatal hypoglycemia, and deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone.
Retinal dystrophy, early-onset, with or without pituitary dysfunction (RDEOP):
An autosomal dominant ocular disease characterized by pattern dystrophy of the retinal pigment epithelium, and photoreceptor degeneration. Mild developmental anomalies include optic nerve head dysplasia, microcornea, and Rathke's cleft cyst. Some patients manifest pituitary dysfunction.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-OTX2 Recombinant Antibody (14H14L5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry