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Rabbit Anti-OTX2 Recombinant Antibody (D7Y3J) (CBMAB-CP1814-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Chicken, Cattle, Guinea pig, Horse
Clone
D7Y3J
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn251 of human OTX2 protein.
Specificity
Human, Mouse, Rat, Monkey, Chicken, Cattle, Guinea pig, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Orthodenticle Homeobox 2
Introduction
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]
Entrez Gene ID
Human5015
Mouse18424
Rat305858
Monkey698501
Cattle395191
Chicken611228
Guinea pig100729098
Horse100050678
UniProt ID
HumanP32243
MouseP80206
RatQ64201
MonkeyA0A1D5QAZ9
CattleE1BNP1
ChickenQ6E236
Guinea pigH0V0U1
HorseA0A3Q2HSX6
Alternative Names
Orthodenticle Homeobox 2; Orthodenticle Homolog 2; Orthodenticle Homolog 2 (Drosophila); Homeobox Protein OTX2; MCOPS5; CPHD6;
Function
Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Biological Process
Axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Dopaminergic neuron differentiationManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Forebrain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Midbrain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Positive regulation of embryonic developmentISS:UniProtKB
Positive regulation of gastrulationISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Primitive streak formationISS:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of smoothened signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Microphthalmia, syndromic, 5 (MCOPS5):
Patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including pituitary dysfunction, coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
Pituitary hormone deficiency, combined, 6 (CPHD6):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD6 patients manifest neonatal hypoglycemia, and deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone.
Retinal dystrophy, early-onset, with or without pituitary dysfunction (RDEOP):
An autosomal dominant ocular disease characterized by pattern dystrophy of the retinal pigment epithelium, and photoreceptor degeneration. Mild developmental anomalies include optic nerve head dysplasia, microcornea, and Rathke's cleft cyst. Some patients manifest pituitary dysfunction.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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