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Mouse Anti-OTX1 Recombinant Antibody (4E5) (CBMAB-A6263-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
OTX1 (NP_055377, 10 a.a. ~ 116 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
orthodenticle homeobox 1
Introduction
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy. [provided by RefSeq]
Entrez Gene ID
5013
UniProt ID
P32242
Alternative Names
FLJ38361; MGC15736
Function
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Biological Process
Anterior/posterior pattern specificationIEA:Ensembl
Diencephalon morphogenesisIEA:Ensembl
Inner ear morphogenesisIEA:Ensembl
Metencephalon developmentIEA:Ensembl
Midbrain developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
More Infomation

Wei, J., Wang, X., Jiao, K., & Liu, H. (2023). Orthodenticle Homeobox OTX1 Promotes Papillary Thyroid Carcinoma Progression and Is a Potential Prognostic Biomarker. Genetics Research, 2023, e33.

Yang, R., Yang, L., Long, M., Wu, F., Shi, Y., Xia, R., ... & Wei, W. (2023). Taurodeoxycholic acid-YAP1 upregulates OTX1 in promoting gallbladder cancer malignancy through IFITM3-dependent AKT activation. Oncogene, 42(18), 1466-1477.

Zhou, L., Li, H., Zhang, D., Chen, L., Dong, H., Yuan, Y., & Wang, T. (2022). OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway. Oncology Reports, 48(5), 1-11.

Jiang, L., Zuo, Z., Lin, J., & Yang, C. (2021). Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer. Bioengineered, 12(1), 6559-6571.

Yang, C. Y., Wang, L., Mu, D. C., Li, F. F., Ran, P. Z., Shen, H., ... & Zheng, S. Y. (2020). OTX1 is a novel regulator of proliferation, migration, invasion and apoptosis in lung adenocarcinoma. European Review for Medical & Pharmacological Sciences, 24(18).

Chen, S., Xu, M., Zhao, J., Shen, J., Li, J., Liu, Y., ... & Shan, T. (2020). MicroRNA-4516 suppresses pancreatic cancer development via negatively regulating orthodenticle homeobox 1. International journal of biological sciences, 16(12), 2159.

Tu, X. P., Li, H., Chen, L. S., Luo, X. N., Lu, Z. M., Zhang, S. Y., & Chen, S. H. (2020). OTX1 exerts an oncogenic role and is negatively regulated by miR129-5p in laryngeal squamous cell carcinoma. BMC cancer, 20, 1-10.

Li, J., Zhao, L. M., Zhang, C., Li, M., Gao, B., Hu, X. H., ... & Wang, G. Y. (2020). The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p. Oncology research, 28(1), 51.

Yang, J., Wu, W., Wu, M., & Ding, J. (2019). Long noncoding RNA ADPGK-AS1 promotes cell proliferation, migration, and EMT process through regulating miR-3196/OTX1 axis in breast cancer. In Vitro Cellular & Developmental Biology-Animal, 55(7), 522-532.

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For research use only. Not intended for any clinical use.

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