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Mouse Anti-ORC2 Recombinant Antibody (CBXO-0402) (CBMAB-O0538-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0402
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human ORC2 (origin recognition complex, subunit 2), using two Recombinant proteins containing the N-terminal and C-terminal part of the protein, respectively
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.6 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Origin Recognition Complex Subunit 2
Introduction
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.
Entrez Gene ID
4999
UniProt ID
Q13416
Alternative Names
Origin Recognition Complex Subunit 2; ORC2L; Origin Recognition Complex, Subunit 2 (Yeast Homolog)-Like; Origin Recognition Complex, Subunit 2 Homolog (Yeast); Origin Recognition Complex, Subunit 2-Like (Yeast); Origin Recognition Complex, Subunit 2 Homolog; Origin Recognition Complex Protein 2 Homolog; Origin Recognition Complex, Subunit 2
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
Biological Process
DNA replication initiationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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